# U.S. Withdrawal from WHO Raises Alarm Over Smallpox Research and Security

Fri Jul 18 2025 12:12:38 GMT+0300 (Eastern European Summer Time)
# U.S. Withdrawal from WHO Raises Alarm Over Smallpox Research and Security

The decision to exit the World Health Organization compromises essential safeguards against one of humanity’s most lethal pathogens.


Health experts caution that the Trump administration's departure from key global health collaborations endangers the ongoing research and secure management of smallpox virus remnants.

In a significant shift for global health policy, President Trump’s decision to withdraw the United States from the World Health Organization (WHO) could have dire implications for smallpox research and security, igniting widespread concern among health experts. The withdrawal threatens decades of rigorous oversight established to manage the remaining smallpox virus, a pathogen that historically claimed over 500 million lives worldwide.

Former CDC director Thomas R. Frieden shared insights from his extensive experience researching the virus, likening the secure labs housing the American smallpox samples to "a submarine inside a building," underscoring the heightened safety protocols in place. The abrupt cessation of WHO oversight is poised to undermine these safety measures, potentially opening the door for catastrophic mismanagement or accidental release of the virus into the environment.

Dartmouth medical professor Daniel R. Lucey amplified these fears in a recent article, stressing that this exit could disrupt crucial operations related to the storage, experimentation, reporting, and inspection of smallpox. The WHO’s role has been pivotal; it orchestrated the global eradication of smallpox from human populations over 50 years ago—a remarkable achievement in medical science hailed as a benchmark of international cooperation.

Following the virus's eradication, only two official repositories remain: one located in Atlanta, Georgia, and the other in Russia. Both are maintained under stringent Biosafety Level 4 conditions, ensuring maximum safety against any potential leaks. Without the WHO’s regulatory guidelines, questions surrounding the future management of these caches arise, particularly regarding fears that the U.S. could, under a shroud of secrecy, explore weaponization of the smallpox virus under the guise of research.

Experts continue to stress the urgency of transparency and inspection in mitigating risks associated with these virus stores. “To reduce smallpox risks, we need to open ourselves up to inspection,” Frieden reiterated, underlining the need for international collaboration to protect public health worldwide. The implications of this withdrawal extend far beyond the laboratory walls, posing threats to global safety and understanding of a historic yet dangerous virus.

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