Describing her concerns, Caroline Kennedy highlighted RFK Jr.’s long history of vaccine skepticism and his promotion of discredited ideas linking vaccines to autism. She contended that such views are dangerous, saying, “He lacks any relevant government, financial, management, or medical experience.” The appointment carries significant implications since the Health and Human Services Secretary oversees major public health institutions, such as the CDC and FDA.

Kennedy further illustrated her point by alleging that RFK Jr. exploits the desperation of parents of sick children while being hypocritical about vaccinating his own kids. "Bobby preys on the desperation of parents," she asserted. Alongside criticisms of his health policies, Caroline Kennedy touched on RFK Jr.’s troubling personal history with substance abuse, suggesting that his lifestyle has had negative influences on their extended family.

Moreover, Kennedy accused RFK Jr. of historical cruelty toward animals, recalling incidents from their shared childhood. As an impactful rebuttal, she claimed that both her father, former President John F. Kennedy, and her uncle, Robert F. Kennedy, would be "disgusted" by his behavior.

As RFK Jr. braces for intense scrutiny during the upcoming confirmation hearing, Caroline Kennedy's pointed remarks set the stage for what is likely to be a contentious debate over his suitability for a pivotal health leadership role in the incoming Trump administration.