More than 35 people have been killed in Israeli strikes and gunfire since the early hours of Saturday morning, hospital sources in Gaza say.
A strike on a house in central Gaza left at least 11 people dead - more than half of them women and children, according to officials at al-Ahli Arab hospital in Gaza City.
Health workers reported that nine members of the same family were among those killed in an Israeli strike on the Nuseirat refugee camp, and at least six people are reported to have been killed while seeking aid in central and southern Gaza.
This comes a day after Israeli Prime Minister Benjamin Netanyahu addressed the United Nations, insisting that Israel must finish the job against Hamas.
The Israeli air force stated it hit around 120 targets across the Strip since Friday, targeting what it claims are buildings used by terror groups, terror operatives, and other infrastructure.
The recent offensive is heavily focused on Gaza City, which Israel claims is the last stronghold of Hamas. Hundreds of thousands of residents have fled from this major urban area, where a famine was confirmed last month by a UN-backed entity, yet many remain trapped in dire conditions as health and essential services collapse.
Amid the chaos, residents like Salwa Subhi Bakr express despair: They tell us to go there, then come back here... Where should we go?
According to reports, several members of the Bakr family were killed in a strike on Al-Shati refugee camp.
International calls for a ceasefire have intensified, supported by multiple new recognitions of Palestinian statehood at the UN this week. However, Israel continues its aggressive stance against Hamas.
As Netanyahu reaffirms Israel's position at the UN General Assembly, the humanitarian situation in Gaza deteriorates further, with over 65,549 fatalities reported in the ongoing conflict.